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Astrocytes in depression and Alzheimer’s disease
《医学前沿(英文)》 2021年 第15卷 第6期 页码 829-841 doi: 10.1007/s11684-021-0875-0
关键词: astrocytes depression Alzheimer’s disease roles mechanisms
Protein phosphatase 2A, a key player in Alzheimer’s disease
Rong LIU, Qing TIAN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 8-12 doi: 10.1007/s11684-009-0017-6
关键词: protein phosphatase 2A Alzheimer’s disease holoenzyme composition protein phosphatase 2A inhibitors Leu309 demethylation Tyr307 phosphorylation
Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein
《环境科学与工程前沿(英文)》 2023年 第17卷 第2期 doi: 10.1007/s11783-023-1615-2
● B[a]P, nicotine and phenanthrene molecules altered the secondary structure of Aβ42.
关键词: Polycyclic aromatic hydrocarbons Nicotine toxicology Aβ42 peptide Alzheimer’s disease Molecular dynamics simulations Environmental pollution
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
《化学科学与工程前沿(英文)》 2018年 第12卷 第2期 页码 283-295 doi: 10.1007/s11705-017-1687-2
关键词: Alzheimer’s disease amyloid β-protein cyclic peptide inhibition protein aggregation
et’s disease in a Chinese population
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 354-359 doi: 10.1007/s11684-012-0234-2
Beh?et’s disease is defined as a multisystemic inflammatory disease. Although the precise pathogenesis and etiology is still a mystery, accumulating evidence shows that genetic variants of immune-related genes have a profound influence on the development of Beh?et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population. A large number of gene polymorphisms were studied including STAT4, IL23R, CD40, CCR1/CCR3, STAT3, OPN, IL17, JAK2, MCP-1, CTLA4, PD-1, PD-L1, PD-L2, TGRBR3, CCR6, PTPN22, FCRL3, IRF5, SUMO4 and UBAC2. Significant associations were found between Beh?et’s disease and STAT4, IL23R, CD40, CCR1/CCR3, STAT3, MCP-1, TGFBR3, FCRL3, SUMO4, UBAC2. These genetic predisposition studies support an important role for both lymphocyte differentiation as well as ubiquitination pathways. These findings are helpful in elucidating the pathogenesis of Beh?et’s disease and hopefully will allow the development of novel treatment regimes.
Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong
《医学前沿(英文)》 2021年 第15卷 第1期 页码 125-138 doi: 10.1007/s11684-019-0725-5
关键词: Parkinson’s disease diffusion tensor imaging fractional anisotropy meta-analysis anisotropic effect size–signed differential mapping
Medical applications of phytoestrogens from the Thai herb
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 8-21 doi: 10.1007/s11684-012-0184-8
Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.
关键词: white Kwao Krua miroestrol estrogenic activity reproduction osteoporosis breast cancer Alzheimer
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
关键词: chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
Acupuncture for the management of dry eye disease
《医学前沿(英文)》 2022年 第16卷 第6期 页码 975-983 doi: 10.1007/s11684-022-0923-4
Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development
Long-de Wang
《工程管理前沿(英文)》 2015年 第2卷 第1期 页码 2-12 doi: 10.15302/J-FEM-2015002
关键词: chronic disease prevention and control strategy and system construction
Minimal residual disease in solid tumors: an overview
《医学前沿(英文)》 2023年 第17卷 第4期 页码 649-674 doi: 10.1007/s11684-023-1018-6
关键词: MRD solid tumor CTC ctDNA
Zhonghua Sun
《医学前沿(英文)》 2011年 第5卷 第3期 页码 254-270 doi: 10.1007/s11684-011-0153-7
关键词: cardiovascular disease multislice computed tomography three-dimensional reconstruction diagnosis visualization
Zooming in and out of ferroptosis in human disease
《医学前沿(英文)》 2023年 第17卷 第2期 页码 173-206 doi: 10.1007/s11684-023-0992-z
关键词: ferroptosis human disease iron metabolism lipid peroxidation antioxidation
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 366-375 doi: 10.1007/s11684-012-0214-6
Surveillance is critical for the prevention and control of infectious disease. China’s real-time web-based infectious disease reporting system is a distinguished achievement. However, many aspects of the current China Infectious Disease Surveillance System do not yet meet the demand for timely outbreak detection and identification of emerging infectious disease. PulseNet, the national molecular typing network for foodborne disease surveillance was first established by the Centers for Disease Control and Prevention of the United States in 1995 and has proven valuable in the early detection of outbreaks and tracing the pathogen source. Since 2001, the China CDC laboratory for bacterial pathogen analysis has been a member of the PulseNet International family; and has been adapting the idea and methodology of PulseNet to develop a model for a future national laboratory-based surveillance system for all bacterial infectious disease. We summarized the development progress for the PulseNet China system and discussed it as a model for the future of China’s national laboratory-based surveillance system.
关键词: infectious disease laboratory-based infectious disease surveillance pulse field gel electrophoresis multilocus sequencing typing PulseNet China
标题 作者 时间 类型 操作
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
期刊论文
Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion
Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong
期刊论文
Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development
Long-de Wang
期刊论文
Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations
Zhonghua Sun
期刊论文